We study coupled mechanical and biochemical changes in human disease
What is mechanobiology?
Our research is in the area of Mechanobiology. Mechanobiology is the scientific study of the mechanisms by which cell generated mechanical forces and/or the cellular mechanical environment impact cell and tissue structure and function. We are particularly interested in the mechanobiology of human diseases including cancer.
We are funded by the National Cancer Institute’s Physical Sciences and Oncology Network (PSON).
Dr. Lele is a member of the NIH study section
Dr. Lele was recently elected Fellow of the Biomedical Engineering Society
Dr. Lele is a CPRIT scholar
Dr. Lele is Unocal Professor at TAMU
Dr. Lele's google scholar profile
Paper on the nuclear drop model published in Current Opinion in Biomedical Engineering
New model published in Frontiers in Cell and Developmental Biology that explains nuclear shapes in cultured cells
Vani Narayanan’s paper reporting that Rho activation causes acinar eversion is published in Biophysical Journal
Review published in J Biol Chem on the role of glycans in Mechanobiology