We study coupled mechanical and biochemical changes in human disease

Principal Investigator

Dr. Tanmay Lele, Ph.D.


Ph.D. Students

Christina Dubell

Ph.D. Students

Aditya Katiyar

Ph.D. Students

Mohammad Mohajeri

Ph.D. Students

Ting-Ching Wang

Ph.D. Students

Purboja Purkayastha

Ph.D. Students

Brendan Mckee

Lab Coordinator

Kavya Pendyala

What is mechanobiology?

Our research is in the area of Mechanobiology. Mechanobiology is the scientific study of the mechanisms by which cell generated mechanical forces and/or the cellular mechanical environment impact cell and tissue structure and function. We are particularly interested in the mechanobiology of human diseases including cancer.


We are funded by the National Cancer Institute’s Physical Sciences and Oncology Network (PSON).

Dr. Lele is a member of the NIH study section

The Lele lab is a part of the Gulf Coast Consortia

Dr. Lele is a CPRIT scholar

Dr. Lele is Unocal Professor at TAMU

Dr. Lele's google scholar profile

May 2022

New paper accepted in Advanced Science on the discovery that the cell nucleus deforms like a drop in migrating cells

March 2022

New paper accepted in Molecular Biology of the Cell on a small molecule screen against nuclear morphology

Dec 2021

American Institute of Physics showcases new paper on “Viscous shaping of the compliant cell nucleus” in a Scilight article

8 April, 2021

Purboja Purkayastha and Kavya Pendyala published a new paper in “Molecular Biology and Evolution”

Associations with