Publications

2017 |2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001

2017

Tocco, V.J., Neelam, S., Zhang, Q., Dickinson, R.B., and Lele, T.P. (2017), Nuclear forcing in the living cell, Methods in Molecular Biology. In press.

Tocco, V.J., Li, Y., Christopher, K.G., Matthews, J.H., Aggarwal, V., Paschall, L, Luesch, H., Licht, J.D., Dickinson, R.B., and Lele, T.P. (2017), The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells, Journal of Cellular Physiology. DOI:10.1002/jcp.26031.  JCP spotlight article

2016

Aggarwal, V., and Lele, T.P. (2016), Intracellular concentration gradients that mirror external gradients in microfluidic flows: a computational analysis, Cellular and Molecular Bioengineering. DOI:10.1007/s12195-016-0474-3. 

Alam, S., Zhang, Q., Prasad, N., Li, Y., Chamala, S., Kuchibhotla, R., KC, B., Aggarwal, V., Shrestha, S., Jones, A., Levy, S., Roux, K., Nickerson, J., and Lele, T.P. (2016). The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity, Scientific Reports. DOI:10.1038/srep38063.

Kent, I. and Lele, T.P. (2016). Microtubule-Based Force Generation, WIREs Nanomed Nanobiotechnol. DOI:10.1002/wnan.1428.

Torbati, M., Lele, T.P., and Agrawal, A.(2016). On the Ultra-Donut Topology of The Nuclear Envelope, Proceedings of the National Academy of Sciences, vol. 113, no. 40, 11094-11099. DOI: 10.1073/pnas.1604777113. 

Kent, I., Rane, P.S., Dickinson, R.B., Ladd, A.J.C., and Lele, T.P. (2016). Transient Pinning and Pulling: A Mechanism for Bending Microtubules, PLoS ONE 11(3):e0151322.

Aggarwal, V., Dickinson, R.B., and Lele, T.P. (2016). Concentration sensing by the moving nucleus in cell fate determination: a computational analysis, PLoS ONE 11(2): e0149213.

Torbati, M., Lele, T.P., and Agrawal, A. (2016). An unresolved LINC in the nuclear envelope. Cellular and Molecular Bioengineering 9(2): 252–257. DOI:10.1007/s12195-016-0431-1.

Neelam, S., Hayes, P., Zhang, Q., Dickinson, R. B., and Lele, T. P. (2016). Vertical uniformity of cells and nuclei in epithelial monolayers. Published online in Scientific Reports. DOI:10.1038/srep19689. Access the recommendation on F1000Prime

2015

Zhang, Q., Kota, K. P., Alam, S. G., Nickerson, J. A., Dickinson, R. B., and Lele, T. P. (2015). Coordinated dynamics of RNA splicing speckles in the nucleus. Journal of Cellular Physiology. 231: 1269–1275, 2016. DOI: 10.1002/jcp.25224. Article Highlighted and chosen for Cover Art.

Dickinson, R.B., Neelam, S., and Lele, T.P. (2015). Dynamic, mechanical integration between nucleus and cell- where physics meets biology, Nucleus, 6(5), 360-365.

Li, Y., Lovett, D., Zhang, Q., Neelam, S., Kuchibhotla, R.A., Zhu, R., Gundersen, G.G., Lele, T.P., and Dickinson, R.B. (2015). Moving cell boundary drives nuclear flattening during cell spreading, Biophysical Journal, 109 (4), 670-686.

Neelam, S., Dickinson, R.B., and Lele, T.P. (2015). New approaches for understanding the nuclear force balance in living, adherent cells, Methods 94 (2016) 27–32.

Dickinson, R.B., and Lele, T.P. (2015). Chemical engineering principles in the field of cell mechanics, Industrial & Engineering Chemistry Research, 54 (23), pp 6061–6066. DOI: 10.1021/acs.iecr.5b01330 

Neelam, S., Chancellor, T.J., Li, Y., Nickerson, J., Roux, K., Dickinson, R.B., and Lele, T.P. (2015). A direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell, Proceedings of the National Academy of Sciences, vol 112, no.18, 5720-5725. DOI: 10.1073/pnas.1502111112.
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Alam, S.G., Lovett, D., Kim, D.I., Roux, K., Dickinson R.B., and Lele T.P. (2015). The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts, Journal of Cell Science, 128 (10), 1901-1911. Highlighted by the journal in its ‘In this issue’ section. 

2014

Wu J., Kent I.A., Shekhar N., Chancellor T.J., Mendonca A., Dickinson R.B., and Lele T.P. (2014). Actomyosin pulls to advance the nucleus in a migrating tissue cell, Biophysical Journal, 106, 7-15.

Book Chapter
Alam S. G., Lovett D., Dickinson R.B., Roux K., and Lele T.P., Nuclear Forces and Cell Mechanosensing. In: Engler A.J and Kumar S., eds.: Mechanotransduction, Vol 126, Progress in Molecular Biology and Translational Science, UK: Academic Press, 2014, pp.205-216. Pubmed ID 25081619

2013

Lewis J.S., Dolgova N., Chancellor T.J., Acharya A.P., Karpiak J.V., Lele T.P., Keselowsky B.G. (2013). Dendritic cell activation is influenced by cyclic mechanical strain when cultured on adhesive substrates.  Accepted for publication in Biomaterials, August, 2013.

Shekhar N., Neelam S., Wu J., Ladd A., Dickinson R.B., and Lele T.P. (2013). Fluctuating Motor Forces Bend Growing Microtubules. Cellular and Molecular Bioengineering, 6(2):120-129. One of four award publications chosen by CMBE for 2013.

Lovett D.B., Shekhar N., Nickerson J.A., Roux K., Lele T.P. (2013). Modulation of nuclear shape by substrate rigidity. Cellular and Molecular Bioengineering, 6(2):230-238. Access the recommendation on F1000Prime

Shekhar N., Wu J., Dickinson R.B. and Lele T.P. (2013). Cytoplasmic Dynein: Tension Generation on Microtubules and the nucleus.  Cellular and molecular Bioengineering, 6(1), 74-81.

2012

Wu J., Shekhar N., Lele P.P., Lele T.P. (2012). FRAP Analysis: Accounting for Bleaching during Image Capture. PLoS ONE 7(8): e42854.

Wu J. , Dickinson R.B., Lele T.P. (2012). Investigation of in vivo Microtubule and Stress Fiber Mechanics with Laser Ablation (Review article). Integrative Biology, 4, 471–479.

2011

Wu J., Misra G., Russell R. J., Ladd A., Lele T.P., Dickinson R.B. (2011). Effects of Dynein on Microtubule Mechanics and Centrosome Positioning. Molecular Biology of the Cell, vol. 22 no. 24: 4834-4841.

Wu J., Lee K.C., Dickinson R.B., Lele T.P. (2011). How Dynein and Microtubules Rotate the Nucleus. Journal of Cellular Physiology, 226: 2666-2674. (Highlighted article) Highlighted by the journal. 

Russell R.J., Grubbs A., Mangroo S., Nakasone S., Dickinson R.B. and Lele T.P. (2011). Sarcomere Length Fluctuations and Flow in Capillary Endothelial Cells. Cytoskeleton, 68(3):150-6.

2010

Lee J., Wang Y., Ren F. and Lele T.P. (2010). A Stamp Wound Assay for Studying Coupled Cell Migration and Cell Debris Clearance, Langmuir 2010 Nov 16;26(22):16672-6.

Lee J, Chu B.H., Sen S., Gupte A., Chancellor T.J., Chang C.-Y., Ren F., Kumar S., and Lele T.P. (2010). Modulating malignant epithelial tumor cell adhesion, migration, and mechanics with nanorod surfaces. Biomedical Microdevices 2011 Feb;13(1):89-95.

Chancellor T.J., Lee J., Thodeti C. and Lele T.P. (2010) “Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration and cyclic strain induced reorientation”, Biophysical Journal, 2010 Jul 7;99(1):115-23.
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Zaveri T.D., Dolgova N.V., Chu B.H., Lee J., Wong J., Lele T.P., Ren F., Keselowsky B.G.(2010) “Contributions of surface topography and cytotoxicity to the macrophage response to zinc oxide nanorods.”, Biomaterials, 31(11):2999-3007.

2009

Russell R.J., Xia S-L, Dickinson R.B. and Lele T.P. (2009). Sarcomere mechanics in capillary endothelial cells. Biophysical Journal, 97 (6), 1578-1585.

Lee J., Chu B.H., Chen K.H, Ren F., Lele T.P. (2009) “Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells”, Biomaterials, 30, 4488–4493

2008

Lee J., Kang B.S., Chancellor T.J., Chu B.H., Wang H.T., Keselowsky B., Ren F. and Lele T.P., “The control of cell adhesion and viability by zinc oxide nanorods”, Biomaterials, 29 (2008) 3743–3749

Luo Y., Xu X., Lele T.P., Kumar S. and Ingber D.E., “A multimodular tensegrity model for an actin stress fiber”, Journal of Biomechanics, 2008 Aug 7;41(11):2379-87

Lele TP, Thodeti C, Pendse J and Ingber DE, “Investigating complexity of protein-protein interactions in focal adhesions”, Biophysical and Biochemical Research Communications, 2008 May 9;369(3):929-34

2007

Kang BS,Wang HT, Lele TP, Ren F, Pearton SJ, Johnson JW, Rajagopal P, Roberts JC, Piner EL and Linthicum KJ, “Prostate specific antigen detection using AlGaN/GaN high electron mobility transistors”, Applied Physics Letters, In press.

Pearton S, Lele TP, Tseng Y and Ren F, “Penetrating living cells with semiconductor nanowires”, Trends in Biotechnology, In press.

Lele TP, Sero JE, Matthews BD, Kumar S, Xia S, Montoya-Zavala M, Polte T, Overby D, Wang N, Ingber DE. “Tools to study cell mechanics and mechanotransduction”, Methods in Cell Biology 2007;83:441-72.

Lele TP and Kumar SK, “Brushes, cables and ratchets: Recent insights into multiscale assembly and mechanics of cellular structural networks”, Cell Biochemistry and Biophysics, 47: 348-360 (2007).

Chancellor TJ, Russell R and Lele TP, “Toward in-situ biochemistry: combining chemical kinetics approaches with bio-molecular imaging in living cells”, Biotechnology Progress, In press.

Wang HT, Kang BS, Chancellor TJ, Lele TP, Tseng Y, Ren F, Pearton SJ, Johnson JW, Rajagopal P, Roberts JC, Piner EL and Linthicum KJ, “Selective Detection of Hg(II) ions from Cu(II) and Pb(II) Using AlGaN/GaN High Electron Mobility Transistors”, Electrochemical and Solid-State Letters, In press.

Pearton SJ, Ren F, Kang BS, Wang HT, Gila BP, Norton DP, Tien LC, Chancellor TJ, Lele TP, Tseng Y and Lin J, “GaN and ZnO based sensors for Bio, Nuclear Materials and Chemical Detection”, Proceedings of the Electrochemical Society Meeting, Washington, 2007

Wang HT, Kang BS, Chancellor TJ, Lele TP, Tseng Y, Ren F, Pearton SJ, Johnson JW, Rajagopal P, Roberts JC, Piner EL and Linthicum KJ “Fast electrical detection of Hg(II) ions with AlGaN/GaN high electron mobility transistors”, Applied Physics Letters, in press

Book Chapter

Goldman W, Bechinger B and Lele TP, Cytoskeletal proteins at the lipid membrane. In: A. Leitmannova Liu., ed., Advances in lipid biolayers and liposomes, Planar lipid bilayers (BLM’s) and their applications, Elsevier in press

Lele TP and Ingber DE, Focal adhesions: self-assembling nanoscale mechano-chemical machines that control cell function. In: Nair L, Laurencin C, Halberstadt C, Gonsalves K, eds., Biomedical Nanostructures, John Wiley & Sons ­ In Press.

2006

Lele TP, Pendse J, Kumar S, Salanga M and Ingber DE, “Mechanical forces alter zyxin unbinding kinetics within focal adhesions in living cells”, Journal of Cellular Physiology, 207: 187-94 (2006).

Lele TP, Wagner S, Nickerson J and Ingber DE, “Methods for measuring rates of protein binding to insoluble scaffolds in living cells: Histone H1-chromatin interactions”, Journal of Cellular Biochemistry, 2006 Dec 1;99(5):1334-42.

Lele TP, Thodeti C and Ingber DE, “Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using Fluorescence Recovery After Photobleaching”, Journal of Cellular Biochemistry, 97: 1175-83 (2006).

Sharp D, Mancini MG, Hinojos C, Dai F, Berno V, Szafran A, Smith KP, Lele TP, Ingber DE and Mancini MA, “Estrogen-receptor-a exchange and chromatin dynamics are ligand- and domain- dependent”, Journal of Cell Science, 119, 4101-4116 (2006).

Kumar S, Maxwell IZ, Heisterkamp A, Polte TR, Lele TP, Salanga M, Mazur E, Ingber DE, “Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization and extracellular matrix mechanics”, Biophysical Journal, 90: 3762-73 (2006).

Lele TP and Ingber DE, “A mathematical model to determine molecular kinetic rate constants under non-steady conditions using FRAP”, Biophysical Chemistry, 120 (1): 32-35 (2006).

2005
McMillan N, Lele TP, Snively C and Lauterbach J, “Subsurface oxygen on Pt(100): experiments and modeling”, Catalysis Today, 105: 244-253 (2005).

2004

Lele TP, Oh P, Nickerson J and Ingber DE, “An improved mathematical approach for determination of molecular kinetics in living Cells with FRAP”, Mechanics and Chemistry of Biosystems, 1: 181-190 (2004).

2003

Lele TP, Lauterbach J, and Ramkrishna D, “Mathematical Analysis of physicochemical processes on catalytic surfaces”, AICHE J, 49: 2158-2172 (2003).

Desai R, Lele TP and Viens F, “A Monte Carlo method for portfolio optimization under partially observed stochastic volatility”, IEEE international conference on computational intelligence for financial engineering, 257-263 (2003).

2002

Lele TP and Lauterbach J, “Spatio-temporal pattern formation during CO oxidation on Pt(100) at low and Intermediate Pressures: A Comparative Study”, Chaos, 12:164-171. (2002).

2001

Lele TP and Lauterbach J, “Spatio-Temporal Pattern Formation During CO Oxidation on Pt(100) at Elevated Pressures”, AICHE J, 47:1418-1424 (2001).

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