We are located in the Department of Chemical Engineering at the University of Florida.
Cells in our body perform complex tasks, including movement across tissues, adhesion to polymeric scaffolds in the body and the sensing of chemical and mechanical signals. These complex processes depend in large part on the intracellular cytoskeleton. Specialized ‘motor’ proteins that convert chemical energy into mechanical work associate and move along the polymeric cytoskeleton enabling critical cell functions including intracellular mechanical force generation. We are interested in how the cytoskeleton and associated motor proteins generates forces inside the living cell. This work has applications in understanding diseases of the cardiovascular and muscular system, as well as cancer. We are also developing new biomaterials and nanotechnologies for characterizing and controlling cellular forces.
News & Events
May 08: New paper “Repair of nuclear ruptures requires barrier-to-autointegration factor” accepted in the Journal of Cell Biology.
April 21: “Apical cell protrusions cause vertical deformation of the soft cancer nucleus” published in the Journal of Cellular Physiology.
January 31: Andrew Tamashunas won the Food, Pharmaceutical and Bioengineering Division student poster presentation competition from the 2018 AIChE Annual Meeting . Congratulations!
December 7: New paper “Local, transient tensile stress on the nuclear membrane causes membrane rupture” accepted in Molecular Biology of the Cell.