We are located in the Department of Chemical Engineering at the University of Florida.
Cells in our body perform complex tasks, including movement across tissues, adhesion to polymeric scaffolds in the body and the sensing of chemical and mechanical signals. These complex processes depend in large part on the intracellular cytoskeleton. Specialized ‘motor’ proteins that convert chemical energy into mechanical work associate and move along the polymeric cytoskeleton enabling critical cell functions including intracellular mechanical force generation. We are interested in how the cytoskeleton and associated motor proteins generates forces inside the living cell. This work has applications in understanding diseases of the cardiovascular and muscular system, as well as cancer. We are also developing new biomaterials and nanotechnologies for characterizing and controlling cellular forces.
News & Events
Dec, 2016, new paper: “The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity” is published online in Scientific Reports.
November, 2016, Varun Aggarwal successfully defended his thesis :”Mathematical Modeling of Cytoplasmic Gradients: Sampling by the Moving Nucleus.” Congratulations, Dr. Aggarwal.
October, 2016, Srujana Neelam’s article, “Vertical uniformity of cells and nuclei in epithelial monolayers”, Scientific Reports, 2016, has been recommended in F1000Prime as being of special significance in its field. Congratulations!
July, 2016, Ian Kent successfully defended his thesis, “Interphase Microtubules: Mechanics and Nuclear Interactions”. Congratulations, Dr. Kent!