We are located in the Department of Chemical Engineering at the University of Florida.
Cells in our body perform complex tasks, including movement across tissues, adhesion to polymeric scaffolds in the body and the sensing of chemical and mechanical signals. These complex processes depend in large part on the intracellular cytoskeleton. Specialized ‘motor’ proteins that convert chemical energy into mechanical work associate and move along the polymeric cytoskeleton enabling critical cell functions including intracellular mechanical force generation. We are interested in how the cytoskeleton and associated motor proteins generates forces inside the living cell. This work has applications in understanding diseases of the cardiovascular and muscular system, as well as cancer. We are also developing new biomaterials and nanotechnologies for characterizing and controlling cellular forces.
News & Events
October, 2016, Srujana Neelam’s article, “Vertical uniformity of cells and nuclei in epithelial monolayers”, Scientific Reports, 2016, has been recommended in F1000Prime as being of special significance in its field. Congratulations!
July, 2016, Ian Kent successfully defended his thesis, “Interphase Microtubules: Mechanics and Nuclear Interactions”. Congratulations, Dr. Kent!
July, 2016, new paper: “On the Ultra-Donut Topology of The Nuclear Envelope” accepted for publication in Proceedings of the National Academy of Sciences.
April, 2016, Samer Alam successfully defended his thesis, “Nuclear Forces and Gene Expression: an Analysis in Fibroblasts”. Congratulations!